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Diversity of Human Colonic Butyrate-Producing Bacteria Revealed by Analysis of the Butyryl-CoA:acetate CoA-Transferase Gene

That substitution is important because it gives the fragment its fat-targeting properties without activating the broader growth hormone receptor pathways that cause problems like insulin resistance and abnormal tissue growth

Overall, clinical trials consistently demonstrate a dose-dependent effect, with higher maintenance doses producing greater average weight loss

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