Physiologic mechanisms Modulated inflammation: PRP can shift the local milieu from catabolic to anabolic by down-regulating NF-B pathways and promoting anti-inflammatory cytokines (e.g., IL-10) in some formulations
As for the incident patients, an increase from 1.8 patients/1000 inhabitants in 2019 to 7.4 patients/1000 inhabitants in 2023 could be observed (Table 1 (Panel B))
Reizine F, Lesouhaitier M, Gregoire M, Pinceaux K, Gacouin A, Maamar A, et al
Acknowledgments We wish to thank the Spanish network of Emerging crops for the diversification of agronomic and food systems through the use of crops with high nutritional value, project RED2022-134382-T funded by the Spanish Ministry of Science, Innovation and Universities and Carlos Garca and his team from the company Innovaciones Agroalimentarias S.L., Valladolid, Spain, for critical comments and stimulating discussions of the manuscript