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Broader Cellular Pathways While PT-141 is more biased toward MC-3R and MC-4R, some evidence suggests that it may retain activity at MC-1R

The Journal of clinical investigation, 1993, 92(5): 2368-2376

Experimental work in isolated vascular tissue and cell culture models indicates interactions involving regulators such as endothelial nitric oxide synthase, Src kinase signaling, and vascular endothelial growth factor receptor pathways