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The succinate receptor is coupled to numerous different G-proteins including G q , G s , and G i that allow it to activate a variety of divergent and convergent signal transduction pathways

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Hypotension and Syncope Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of WEGOVY-treated adult patients versus 0.4% of placebo-treated patients and syncope was reported in 0.8% of WEGOVY-treated patients versus 0.2% of placebo-treated patients