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Third, the primary outcome tool used in this study, the CAT phlegm score, is not widely used

As expected, treatment with DEM, started at 72 hours after knock-down initiation, leads to a significantly reduced response compared to siCtrl (Fig 3A)

In radiotherapy, the radiation dose must be high enough in the tumor volume to kill all the tumor cells, whereas in electrochemotherapy the electric field in the tumor volume needs to be sufficiently strong and the exposure long enough to cause cell membrane electroporation (33)