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The metabolic adaptations that contributed to weight lossincluding reduced hunger signalling and delayed gastric emptyingdiminish as the medication clears from the system

Consistent with this, co-administration of the GLP-2R agonist h(Gly 2 )GLP-2 and exendin-4 increases small intestinal weight and length to a greater extent compared to the agonists administered alone (Koehler et al., 2015)

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