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3-methyl-4-nitrophenol (PNMC), a byproduct of insecticides and fuel combustion, impair mitochondrial function and ATP production in oocytes, disrupts spindle assembly, increases ROS levels, and induces apoptosis [94]

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In parallel, the microbiota may also influence vitamin D metabolism by modulating CYP27B1 expression, bile acid recycling, and SCFA production