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The real cautions are megadosing vitamin A (especially in pregnancy), taking iron without a confirmed deficiency, high-dose biotin distorting blood test results, and vitamin K products if you're on blood thinners

The metal chelating protein like metallothionine also participates in buffering of redox as well as DNA repair in addition to its generic metal chelating activities

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Consensus of Chinese experts on oral hypoglycemic drugs combined with initial insulin in the treatment of type 2 diabetes mellitus