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In a retrospective study in Korea, metformin and DPP4i was found to be effective in reducing HbA1c below 7%, with a low incidence of hypoglycemia [92].In tacrolimus-induced SD rat model and nephrotoxicity test, DPP4i and sodiumglucose transporter 2 inhibitors (SGLT2i) reduced blood glucose level and HbA1C level, and increased plasma insulin level and islet size of rats, and improved renal function and reduced interstitial fibrosis and pro-fibrotic cytokines, which providing a theoretical basis for the combination of SGLG2i and DPP4i in the treatment of tacrolimus-induced DM and nephrotoxicity [93]

LIPO-010 (Phase III, n=412) Falutz et al

Hundreds of people have reported problems with their pancreas linked to taking weight-loss and diabetes jabs, prompting health officials to launch a new study into their side effects