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Monotreme GLP-1 elicits a different signalling cascade compared to hGLP-1 when binding to the GLP-1 receptor Closer examination of potencies in receptor activation revealed differential signalling bias for monotreme GLP-1 peptides in comparison to that elicited by hGLP-1

Results after 8 weeks: Body weight: 8.1% Waist circumference: 8.2% Testosterone: 128.5% (more than doubled) Estrogen: 60.8% Group B Testosterone (TRT) + Lifestyle Medication Used: Transdermal testosterone gel (AndroGel 1.62%) Starting Dose: 23 mg/day, applied to the upper arms/shoulders for the first 14 days

Retatrutide uses a triple receptor mechanism (GIP, GLP-1, and glucagon) while Mounjaro targets only two receptors (GIP and GLP-1)

Statistics Data are expressed as mean S.E.M