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Warning & Precautions Pregnancy LACARNIT 330MG TABLET must be used with caution in pregnant women and those who are planning to get pregnant due to a lack of safety data

doi: 10.1016/S0140-6736(18)32279-7 5

ECM-based biomarkers reflecting MMP-9 activity, such as C3M (MMP-9 mediated degradation of type III collagen) and C4M (MP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in Hurley stages II and III of HS and show a moderate-strong correlation with the IHS score, indicating their utility in assessing disease activity and severity [104] (Table 1, Fig

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