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TGF- signaling Fibrosis is driven by a complex interplay of pathological processes, including activation of TGF-, dysregulated chemokine expression, metabolic dysfunction, cellular senescence, mitochondrial and endoplasmic reticulum (ER) stress, autophagy, DNA damage, and apoptosis [20, 33, 36, 37]

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For example, POS leads to an immediate increase in hippocampal apoptosis [168, 169] associated with later-life cognitive deficits [168]

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