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Notably, inhibition of MAPK/ERK signalling exacerbates 3-HK-induced mitochondrial dysfunction and cell death, implicating impaired cellular resilience pathways in amplifying KYN-mediated toxicity

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Biochemical Analysis Molecular Analyses Phosphorylated Tau protein in the brain tissue of sacrificed rats was determined using Western blot, while inflammation parameters TNF and IL-1 were assessed using an ELISA kit