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Science 306 , 11381139 (2004)

demonstrated in mice that chronic inflammation, induced by the knockout of the nfkb1 subunit of the NF-B transcription factor, exacerbates telomere dysfunction and cell senescence through a feedback loop involving NF-B, COX-2, and ROS, thereby leading to premature aging and reduced tissue regeneration in liver and gut (Jurk et al., 2014)

Ishy, P