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In a systematic review of 129359 patients from 1958 to 2021, the annual rate of decline in GFR ranged from 0.37 to 1.07 mL/min/1.73 m2/year in healthy adults without hypertension (Guppy et al., 2024)

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Wang G, Bonkovsky HL, de Lemos A, Burczynski FJ (2015) Recent insights into the biological functions of liver fatty acid binding protein 1

The MHRA has warned that this may increase the risk of residual stomach contents during general anaesthesia or deep sedation, even after standard fasting