The ChaC1 and ChaC2 enzymes show around 50% of sequence homology and specifically degrade glutathione but no other -glutamyl peptides or oxidized glutathione [22,23]
The senolytic effects varied between inducers and cell lines, but we identified 38 fragments (with diverse warheads, including chloroacetamides, cyanoacrylamides, acrylamides, aldehydes or sulfonyl fluorides) that selectively killed senescent cells in at least one of the three senescent conditions analysed (Fig
[DOI] [PubMed] [Google Scholar] 76.Bellicha A, van Baak MA, Battista F, Beaulieu K, Blundell JE, Busetto L, Carraa EV, Dicker D, Encantado J, Ermolao A, Farpour-Lambert N, Pramono A, Woodward E, Oppert J-M
It is well-known for preventing neural tube defects like spina bifida in babies