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PICOS framework and eligibility criteria to provide methodological clarity, the research scope and eligibility criteria were strictly defined using the PICOS framework: Population: adults with obesity or overweight (with or without diabetes) or adults with type 2 diabetes mellitus (T2DM)

First large, multi-institutional study which occurred at institutions where the IMPRESS trial was instituted for the routine treatment of PD

Immunofluorescence and quantitative reverse-transcriptase PCR (qRT-PCR) analyses confirmed that the expression of SST in the pancreatic islets, stomach and brain of the Sst Cre R26 DTA mice was abrogated compared with the expression in their Sst-cre littermates (Figs

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