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Extracellular cystine will be transported into cell and reduced to cysteine for the synthesis of glutathione (GSH) ( In addition to the above typical pathways that regulate cellular susceptibility to ferroptosis, several others also play a role
This result indicates that ferroptosis contributes to the antitumor effect induced by SYNCRIP depletion
The processes involve endoplasmic reticulum-associated degradation (ERAD) and are closely related to ubiquitination and proteasomal degradation functions of the UPS pathway [44,45,46]
It is an unapproved research chemical presented here for research and educational purposes only
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