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Environmental Toxins: Exposure to endocrine-disrupting chemicals (EDCs) in food, water, and products can interfere with hormone production

More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

Funding The study was supported by funding from Novo Nordisk Portugal, Lda, which provided consulting fees to Ossian Health Economics and Communications

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