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In a landmark double-blind, placebo-controlled crossover study of 20 men with psychogenic and organic erectile dysfunction, Melanotan II induced penile erections in 17 of 20 subjects (85%) in the absence of sexual stimulation

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Consistent with established principles, CL maturation begins before birth, making PMA more physiologically relevant than postnatal age ( versus age to describe CL maturation (Supplementary Figure S3), suggesting future studies should expand sample sizes to validate these maturation dynamics