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Identified by CAS Number 2381089-83-2, Retatrutide is widely referenced in metabolic and obesity research literature as the first characterized triple agonist targeting the GIP receptor, GLP-1 receptor, and glucagon receptor (GCGR) simultaneously within a single molecular scaffold

The primary outcome was the first occurrence of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death

What the published research reported A phase-2 randomized trial published in the New England Journal of Medicine in 2023 studied retatrutide in adults with obesity and reported substantial, dose-dependent reductions in body weight over 48 weeks, alongside a gastrointestinal side-effect profile broadly similar to other incretin drugs

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