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Additive Effects on Gastric Emptying: Both peptides slow gastric emptying, but through different receptor systems, creating additive effects that produce more profound and prolonged satiety
Moreover, downregulation of IGF-1R, obtained by antisense strategies, has been reported to elicit a host response leading to eradication of surviving malignant cells in vivo (Resnicoff et al, 1996)
The interest in peptides stems from their potential to combat neurodegeneration in diseases such as retinitis pigmentosa and glaucoma, with epialin being a molecule that can help repair or maintain the machinery lost in optic nerve damage conditions, which model diseases like glaucoma, retinitis pigmentosa, stroke, and traumatic head injury 10s