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It is a secretagogue, and is considered to be an agonist, meaning that it possesses the ability to bind certain receptors of a cell and provokes a cellular response

however, diabetes disturbs this balance and causes atherosclerotic plaque disruption, myocardial fibrosis, and remodeling

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Important precautions include contraindication in pregnancy and breastfeeding, and risk of dehydration that may lead to acute kidney injury, particularly in patients with pre-existing renal impairment