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Vargas et al., 2026)

Nature Reviews Immunology , 9 (11), 799809

Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise

Individuals with a history of cancer or concerning family history may wish to avoid compounds that increase IGF-1 and potentially support cell proliferation