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Hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury model showed significant downregulation of miR-494-3p mRNA expression, upregulation of PGC-1, PINK1, and Parkin protein expression, downregulation of Mfn1, Mfn2, and OPA1 protein expression, and reduction of mitochondrial MMP, suggesting that H/R induced excessive mitophagy in cardiomyocytes

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