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Most community protocols start cagrilintide at 0.25 mg/week once tirzepatide is established, then step up every 4 weeks to 0.5, 1.0, 1.7, and 2.4 mg/week
One study reported a higher, five-fold, increase in GST activity in the liver cytosol of female mice chronically treated with 3 H-1,2-dithiol-3-thione, while the same treatment induced only a 1.4-fold increase in males [31]
In SURMOUNT-1, the most common adverse events at the 15 mg dose included nausea (31%), diarrhea (23%), constipation (11%), and vomiting (12%)
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