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Although targeting the GLP1R signaling pathway is a promising therapeutic strategy, it has been reported however that the incretin effects decrease in humans with the onset of obesity and T2D, thus urging us to uncover the underlying mechanism involved in the loss of GLP1R agonist sensitivity in obese and T2D patients (58, 59)
Without the supervision of a healthcare provider, its easy to take the wrong dosage, overlook serious side effects, or use a drug that has not been properly tested
Jumping straight to a high dose is a recipe for severe nausea, vomiting, and potentially abandoning the protocol altogether
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