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The large accumulation of Pro may be explained by the fact that ABA enhanced the expression of Pro-synthesizing enzyme-encoding genes ( P5CS and P5CR ) and suppressed the expression of Pro-degrading enzyme-encoding genes ( ProDH ) (Liu et al., 2022)

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Pickart and Margolinas gene-expression analyses, expanded across their later reviews, lay out clusters of genes that move when cells meet GHK, including ones tied to DNA repair, antioxidant defense, and matrix organization