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Metsera, launched in 2022, was developing a once-monthly GLP-1 injectable

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Acute Toxicity Mice, intraperitoneal LD50: 750 mg/kg, with no other details provided besides the lethal dose

Across the three treatment groups (dulaglutide 1.5 mg, dulaglutide 0.75 mg, and placebo), there were no cases of diabetic ketoacidosis or amputations, and hypotensive episodes/syncope occurred in 0%, 1% and 1%, genital infections in 0%, 0% and 1%, fractures in 1%, 1% and 1%, and gastrointestinal events in 32%, 21% and 17% of patients, respectively [31]