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p53 controls both apoptosis and senescence by promoting p21 transcription, resulting in cell cycle arrest during DNA repair
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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)
doi: 10.1080/87559129.2021.1928691 275 KumariASinglaRGulianiAYadavSK
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