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Do the benefits outweigh the potential side-effects

Niacin, a closely related form of vitamin B3, is known to transiently impair insulin sensitivity and raise blood glucose levels

And beyond the cost, there is the inconvenience of waiting for a replacement, the possibility of missing doses, and the disruption to a treatment plan that was finally working

Insulin requirement was also decreased by 20%, suggesting an alleviation of insulin resistance due to silimarin treatment. (Kazazis et al., 2014) This is because the compounds found in milk thistle have been found to work in a similar way to some diabetic medication