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Common Side Effects: Mild fatigue, intermittent nausea, constipation, and diarrhea

Headache was reported only in trials of people who took Linzess for irritable bowel syndrome with constipation (IBS-C)

Authors relationships and activities SDP declares grants from AstraZeneca and Boehringer Ingelheim, consulting fees from Applied Therapeutics, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Merck Sharpe and Dohme, Novartis Pharmaceuticals, Novo Nordisk and Sanofi, and honoraria for lectures from AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Merck Sharpe and Dohme, Novartis Pharmaceuticals, Novo Nordisk and Sanofi

More significant changes like reduced wrinkles and improved firmness typically become apparent by 6-8 weeks