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Demand has already begun to outpace supply

While it is generally safe, melatonin is a potent hormone, originally extracted from a cows pineal gland, and it can have a number of adverse effects and drug interactions, ranging from nausea to increased blood pressure

Although there is debate as to whether current GLP-1 agonists can readily cross the bloodbrain barrier, there is evidence to suggest that most do and exhibit CNS activity in humans [50]