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Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass

The medication does not permanently reset metabolic function or appetite regulation, which is why a structured approach to discontinuation and long-term lifestyle modification is critical for maintaining weight loss achievements

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Yes, GLP-1s have been invaluable in helping patients lose weight before plastic surgery