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Compounded medicine is an important safety valve for shortages, but the FDA does not guarantee it is safe or effective and facilities that make compounded medicines, such as 503B outsourcing facilities, dont have to be inspected by the FDA before shipping products

A Phase 2 clinical trial published in the New England Journal of Medicine reported a 24.2% least-squares mean reduction in body weight after 48 weeks in the 12mg retatrutide group under the specific conditions of that study

This bidirectional loop means GLP-1 receptor agonists (GLP-1RAs) do not merely supplement a deficient hormone

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