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24 T2DM has also been associated with reduced mean sex hormone-binding globulin levels, and insulin resistance alone appears to confer an increased risk of proinflammatory semen markers and sperm DNA fragmentation

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A useful discrimination between different PAIS subtypes should be obtained with a composite profiling including biomarkers, questionnaires and functional tests so as to take into account PAIS multidimensionality

Ongoing care is handled through monthly refill questionnaires reviewed remotely by a provider