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In keeping with our findings, previous meta-analyses that included different GLP-1RAs did not reveal a significant association between the use of these drugs and the incidence of acute pancreatitis.9,11 Unlike our meta-analysis, these works assessed different GLP-1RAs (exendin-4-based drugs and human GLP-1 analogues) and focused on studies that had included patients with T2DM

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These include pancreatitis (rare but reported in clinical trials and post-marketing surveillance), gallbladder disease, and acute kidney injury (particularly in the setting of severe dehydration from gastrointestinal effects)

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