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With the right approach, you can mitigate many of these potential long-term risks

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Some novel GLP-1 RAs, such as PT302 and PT320, have data to show that they may reduce levodopa-induced dyskinesia and dopaminergic degeneration, suggesting a potential for synergistic therapy with levodopa

Much of the field is now being built on multi-mechanism approaches: tirzepatide combining GLP-1 and GIP, retatrutide adding glucagon to that mix, and cagrilintide plus semaglutide taking yet another route to polyagonism