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Given all these unknowns, it may be best for Congress to pump the brakes on expanding GLP-1s in Medicare before we have a better understanding of their full value and a way to pay for it.
3.5 Rapid Weight Loss and Lean Mass Reduction Weight loss during GLP-1 therapy includes: Adipose tissue Lean body mass Data from obesity trials indicate that without resistance training and adequate protein intake, a meaningful proportion of weight lost may be lean mass. Reduced protein intake may indirectly influence: Iron intake Zinc intake B12 intake This creates a secondary nutrient risk pathway unrelated to absorption but related to dietary composition
Hypoglycemia risk Although the risk of hypoglycemia with these medications is generally low, combining them could potentially increase this risk, especially in patients also taking insulin or sulfonylureas
Topical collagen: Topical treatments called "collagen creams" frequently comprise intact collagen (too large to penetrate skin), hydrolyzed collagen fragments (slightly smaller), and collagen-stimulating chemicals (peptides, retinoids)
