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OASIS 3 a 44-week efficacy and safety phase 3a trial of once-daily oral semaglutide 50mg versus placebo in 200 Chinese adults with obesity or overweight with one or more comorbidities

However, the rapid and significant weight loss they produce creates unique challenges for body composition and skin elasticity

The labels handle it through the escalation schedule itself: a 2.5 mg starting dosage, increases in 2.5 mg increments after at least four weeks on the current dose, and an explicit direction that treatment response and tolerability be considered when selecting the maintenance dosage

This schedule helps maintain steady medication levels in the body, supporting consistent appetite control, improved high blood sugar regulation, and overall metabolic stability