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GHK-Cu and Skin Biology Research In vitro studies with human adult dermal fibroblasts found that GHK-Cu at concentrations of 0.01, 1, and 100 nM increased production of both elastin and collagen, with all concentrations increasing TIMP1 a key inhibitor of matrix metalloproteinases

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Comp Biochem Physiol B Biochem Mol Biol 121(1):4956 Mentlein R, Gallwitz B, Schmidt WE (1993) Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide- 1(736)amide, peptide histidine methionine and is responsible for their degradation in human serum

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