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[1] The FDA has issued a boxed warning regarding thyroid C-cell tumors observed in rodent studies, with a contraindication in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Deviating from weekly timing disrupts steady-state blood levels and reduces appetite-suppressing effects

Functional half-life and tissue distribution