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They are not intended for human consumption, clinical use, diagnostic use, therapeutic use, veterinary use, cosmetic use, or dietary supplement use

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The reality check: the FDA does not consider it a legal cosmetic or dietary ingredient, and there is real concern that long-term use raises the risk of melanoma (skin cancer) the opposite of what most people assume a tan in a vial would do for skin safety (WebMD)

Activated B vitamins support healthy neurological function, people with MTHFR polymorphisms should avoid folic acid and use either folinic acid or methyl folate