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Administering two peptides at the same site in rapid succession increases local inflammatory response

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ALD alcoholic liver disease, DMT1 divalent metal transporter 1, EPO erythropoietin, FPN ferroportin, HJV hemojuvelin, HSCs hepatic stellate cells, IRPs iron-regulatory proteins, KCs Kupffer cells, LCN2 lipocalin-2, NAFLD nonalcoholic fatty liver disease, SIRT1 sirtuin1, TfR transferrin receptor, TS transferrin saturation, DMT (?) DMT1 expression was reported to be unchanged or increased Targeting iron homeostasis for prevention and treatment of ALD ALD is usually diagnosed at an irreversible advanced stage due to the lack of characterization of the early stages and sensitive biomarkers