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Potential Interactions Between Wegovy and NyQuil Ingredients Paracetamol and dextromethorphan have no clinically significant interaction with semaglutide, but decongestants such as phenylephrine can raise blood pressure and should be used cautiously in those with cardiovascular conditions, which are common comorbidities in people prescribed Wegovy

Most researchers assume that because peptides are endogenous signaling molecules and antidepressants are small-molecule drugs, they operate in separate pharmacological spaces

Russo L, Lumeng CN (2018) Properties and functions of adipose tissue macrophages in obesity