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Although excessive weight loss caused by GLP-1RA may exacerbate frailty in older patients, 24 weeks of daily administration of 3 mg liraglutide resulted in reduced fat mass without decreasing muscle mass in older patients with type 2 diabetes and obesity [15]

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The raft concept was originally proposed to explain the unique sterol- and sphingolipid-enriched composition of the apical PM in epithelial cells (van Meer et al., 1987)