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Furthermore, cytokines released by astrocytes may bind to their specific receptors in the dopaminergic neurons, such as TNFR1 and 2, and activate proapoptotic mechanisms through the activation of caspase 3, caspase 8, and cytochrome c [10]

In SLI, YAP1 inhibits ferroptosis through a dual regulatory mechanism

In primary adrenal insufficiency, decreased cortisol secretion causes a release from negative feedback, and consequently, ACTH levels are high

No established replacement for authorised narcolepsy treatment Historical reports involving DSIP should not be used to replace specialist assessment or evidence-based management of excessive daytime sleepiness