Back Blume, N, Skouv, J, Larson, L-I, et al (Nov 1995) 'Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis', Journal of Clinical Investigations , 96, 2227-35
Glucagon-like peptide-1 1 (GLP-1) is an incretin hormone secreted by the intestinal epithelial endocrine L-cells 2 in response to food
Dietary modifications that may support metabolic health include: Including a source of protein at each meal, as protein can stimulate GLP-1 release Including dietary fibre , particularly soluble fibre from vegetables, legumes, oats, and wholegrains, which may promote GLP-1 secretion through fermentation by gut bacteria Eating regular, balanced meals that align with the NHS Eatwell Guide recommendations Limiting ultra-processed foods high in refined carbohydrates and unhealthy fats Considering fermented foods such as yoghurt, kefir, and sauerkraut, which may benefit overall gut health, though direct effects on GLP-1 require further research Lifestyle factors that support metabolic health include: Regular physical activity , with both aerobic exercise and resistance training showing benefits for glucose metabolism
How it affects existing research For researchers currently working with semaglutide or tirzepatide , retatrutide's approval would expand the toolkit significantly
