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The proposal is expected to cost $25 billion for Medicare combined with $11 billion in federal spending and $3.8 billion in state spending for Medicaid coverage throughout the next decade

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Its triple receptor agonism demonstrates potential benefits for enhanced weight loss and metabolic health, providing benefits over conventional single-receptor therapies

Since semaglutide alters how the intestines contract and move food forward, it may theoretically increase recurrence risk in susceptible individuals, though specific clinical data on this combination remains limited