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This means oral supplementation often requires much higher doses to achieve similar effects

doi: 10.1016/j.ejps.2022.106199 154 ChenYLuYLeeRJXiangG

However, the most thoroughly studied IGF-1R inhibitor, limsitinib, was explored in a phase II study, where it did not significantly alleviate prostate-specific antigen levels after 12 weeks of treatment or increase the overall survival in men with metastatic castrate-resistant prostate cancer (141)